Article
The role of somatic mutation in the pathogenic anti-DNA response.
Annual review of immunology - 1 Jan 1992
Diamond B, Katz J B, Paul E, Aranow C, Lustgarten D, Scharff M D
Abstract excerpt
Anti-DNA antibodies represent a significant autospecificity in systemic lupus erythematosus because they are essentially diagnostic of the disease and they contribute to renal pathology. The molecular genetic characterization of these antibodies from both lupus-prone mice and humans with lupus has shown them to be somatically mutated. In many cases the nature of the mutations suggests that DNA or some...
Topics
- Animals
- Antibodies, Antinuclear
- Autoantigens
- Autoimmune Diseases
- Gene Rearrangement
- Humans
- Mutation