Article
T cell-independent somatic hypermutation in murine B cells with an immature phenotype.
Immunity - 1 Feb 2004
Mao Changchuin, Jiang Liying, Melo-Jorge Milena, Puthenveetil Maya, Zhang Xiuli, Carroll Michael C, Imanishi-Kari Thereza
Abstract excerpt
Somatic hypermutation contributes to the generation of antibody diversity and is strongly associated with the maturation of antigen-specific immune responses. We asked whether somatic hypermutation also plays a role in the generation of the murine immunoglobulin repertoire during B cell development. To facilitate identification of somatic mutations, we examined mouse systems in which only antibodies expressing...
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