Article
Harmful somatic mutations: lessons from the dark side.
Immunological reviews - 1 Apr 1998
Wiens G D, Roberts V A, Whitcomb E A, O'Hare T, Stenzel-Poore M P, Rittenberg M B
Abstract excerpt
The ability of somatic mutation to modify the course of an immune response is well documented. However, emphasis has been placed almost exclusively on the ability of somatic mutation to improve the functional characteristics of representative antibodies. The harmful effects of somatic mutation, i...
Topics
- Animals
- Antibodies, Antiphospholipid
- Antibody Diversity
- B-Lymphocytes
- Genes, Immunoglobulin
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Models, Molecular
- Mutation
- Phosphorylcholine