Article
Harmful somatic mutations: lessons from the dark side.
Immunological reviews - 1 Apr 1998
Wiens G D, Roberts V A, Whitcomb E A, O'Hare T, Stenzel-Poore M P, Rittenberg M B
Abstract excerpt
The ability of somatic mutation to modify the course of an immune response is well documented. However, emphasis has been placed almost exclusively on the ability of somatic mutation to improve the functional characteristics of representative antibodies. The harmful effects of somatic mutation, its dark side, have been far less well characterized. Yet evidence suggests that the number of B cells directed to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.