Relationship between case-control studies and the transmission/disequilibrium test.

Abstract excerpt

Case-control studies provide a powerful approach for detecting disease susceptibility loci that have only a weak to moderate impact on the risk of disease, or markers that are in linkage disequilibrium with such loci. However, since any association detected in a case-control study may result from uncontrolled confounding, evidence for disease-marker associations obtained from such studies must be confirmed by...

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