Article
The problems of using the transmission/disequilibrium test to infer tight linkage.
American journal of human genetics - 1 Aug 2000
Whittaker J C, Denham M C, Morris A P
Abstract excerpt
Family-based association methods such as the transmission/disequilibrium test (TDT) have become very popular during the past few years, often being preferred to case-control studies because family-based approaches avoid the difficulties of ascertainment of appropriate populations of cases and controls for case-control studies. Significant TDT results indicate both linkage and allelic association. However,...
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