Article
The power of linkage detection by the transmission/disequilibrium tests.
Human heredity - 1 Jan 2000
Xiong M, Guo S W
Abstract excerpt
Despite growing interest in the use of transmission/disequilibrium test (TDT)-type analysis in association studies, there has been surprisingly scant attention paid to the issues as to what factors affect the power of the TDT for linkage detection. We demonstrate in this paper that the power is a function of several genetic parameters including the recombination fraction, penetrance, the age of mutant disease...
Topics
- Chromosome Mapping
- Gene Frequency
- Genes, Dominant
- Genes, Recessive
- Humans
- Linkage Disequilibrium
- Models, Genetic
- Mutation
- Recombination, Genetic