Article
Spectroscopic probing of the influence of calcium and the gla domain on the interaction between the first EGF domain in factor VIIa and tissue factor.
European journal of biochemistry - 1 Oct 2000
Osterlund M, Owenius R, Persson E, Lindgren M, Carlsson U, Freskgård P O, Svensson M
Abstract excerpt
The binding of factor VIIa (FVIIa) to tissue factor (TF) initiates blood coagulation. The binary complex is dependent on Ca2+ binding to several sites in FVIIa and is maintained by multiple contacts distributed throughout the various domains. Although the contributions from various residues and domains, including the Ca2+ coordination, to the global binding energy have been characterized, their importance for...
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