Affinity of S100A1 protein for calcium increases dramatically upon glutathionylation.

doi:10.1111/j.1742-4658.2005.04680.x

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Article

Affinity of S100A1 protein for calcium increases dramatically upon glutathionylation.

The FEBS journal - 1 May 2005

Goch Grazyna, Vdovenko Sergiusz, Kozłowska Hanna, Bierzyñski Andrzej

Abstract excerpt

S100A1 is a typical representative of a group of EF-hand calcium-binding proteins known as the S100 family. The protein is composed of two alpha subunits, each containing two calcium-binding loops (N and C). At physiological pH (7.2) and NaCl concentration (100 mm), we determined the microscopic binding constants of calcium to S100A1 by analysing the Ca(2+)-titration curves of Trp90 fluorescence for both the...

Topics

Animals
Calcium
Calcium-Binding Proteins
CapZ Actin Capping Protein
Cattle
Egtazic Acid
Fluorescent Dyes
Glutathione
Mutation
Naphthalenesulfonates
Oligopeptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oxidation-Reduction

Peptide Fragments

Protein Binding

Protein Conformation

S100 Proteins

Tryptophan

Source

Open in PubMed

Identifiers

PMID: 15885104
DOI: 10.1111/j.1742-4658.2005.04680.x

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