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Article

A polymorphism in thrombospondin-1 associated with familial premature coronary artery disease alters Ca2+ binding.

The Journal of biological chemistry - 10 Dec 2004

Hannah Blue-leaf A, Misenheimer Tina M, Pranghofer Michelle M, Mosher Deane F

Abstract excerpt

A single nucleotide polymorphism that results in substitution at residue 700 of a serine (Ser-700) for an asparagine (Asn-700) in thrombospondin-1 is associated with familial premature coronary artery disease. The polymorphism is located in the first of 13 Ca2+ -binding motifs, within a consensus sequence in which Asn-700 likely coordinates Ca2+. Equilibrium dialysis of constructs comprised of the adjoining...

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Identifiers

PMID: 15456750
DOI: 10.1074/jbc.M409632200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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