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Article

Structural bases of the redox-dependent conformational switch in the serpin PAI-2.

Journal of molecular biology - 10 Dec 2004

Lobov Sergei, Wilczynska Malgorzata, Bergström Fredrik, Johansson Lennart B-A, Ny Tor

Abstract excerpt

Depending on the redox-status, the serpin plasminogen activator inhibitor type 2 (PAI-2) can exist in either a stable monomeric or polymerogenic form. The latter form, which spontaneously forms loop-sheet polymers, has an open beta-sheet A and is stabilized by a disulfide bond between C79 (in the CD-loop) and C161 (at the bottom of PAI-2). Reduction of this bond results in a closing of the beta-sheet A and...

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Identifiers

PMID: 15561148
DOI: 10.1016/j.jmb.2004.10.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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