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Article

Key residues involved in calcium-binding motifs in EGF-like domains.

Nature - 9 May 1991

Handford P A, Mayhew M, Baron M, Winship P R, Campbell I D, Brownlee G G

Abstract excerpt

Many extracellular proteins with diverse functions contain domains similar to epidermal growth factor (EGF), a number of which have a consensus Asp/Asn, Asp/Asn, Asp*/Asn*, Tyr/Phe (where the asterisk denotes a beta-hydroxylated residue). These include the coagulation factors IX and X, proteins with two EGF-like domains, the first of which contains the consensus residues. The first EGF-like domain of human factor...

Topics

Amino Acid Sequence
Amino Acids
Binding Sites
Calcium
Calcium-Binding Proteins
Carboxylic Acids
Cloning, Molecular
Epidermal Growth Factor
Hemophilia B
Humans
Ligands
Magnetic Resonance Spectroscopy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Protein Conformation

Source

Identifiers

PMID: 2030732
DOI: 10.1038/351164a0

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2030732-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Key residues involved in calcium-binding motifs in EGF-like domains.PMID 2030732Read ↗

EGF-like domain calcium affinity modulated by N-terminal domain linkage in human fibrillin-1.Semantic proximity Read ↗

Identification of haemophilia B patients with mutations in the two calcium binding domains of factor IX: importance of a beta-OH Asp 64----Asn change.Semantic proximity Read ↗

The calcium binding properties and molecular organization of epidermal growth factor-like domains in human fibrillin-1.Semantic proximity Read ↗

Calcium binding to the first EGF-like module of human factor IX in a recombinant fragment containing residues 1-85. Mutations V46E and Q50E each manifest a negligible increase in calcium affinity.Semantic proximity Read ↗

Investigating structure function relationships in the NOTCH family through large-scale somatic DNA sequencing studiesSemantic proximity Read ↗

Ca2+ Binding to the First Epidermal Growth Factor-like Domain of Human Blood Coagulation Factor IX Promotes Enzyme Activity and Factor VIII Light Chain BindingSemantic proximity Read ↗

A Gly --> Ser change causes defective folding in vitro of calcium-binding epidermal growth factor-like domains from factor IX and fibrillin-1.Semantic proximity Read ↗

Structural consequences of cysteine substitutions C1977Y and C1977R in calcium-binding epidermal growth factor-like domain 30 of human fibrillin-1.Semantic proximity Read ↗

Characterization of the functional defect in factor IX Alabama. Evidence for a conformational change due to high affinity calcium binding in the first epidermal growth factor domain.Semantic proximity Read ↗

Substitution of a cysteine residue in a non-calcium binding, EGF-like domain of fibrillin segregates with the Marfan syndrome in a large kindred.Semantic proximity Read ↗

Sequences required for thrombomodulin cofactor activity within the fourth epidermal growth factor-like domain of human thrombomodulin.Semantic proximity Read ↗

Solution structure of the LDL receptor EGF-AB pair: a paradigm for the assembly of tandem calcium binding EGF domains.Semantic proximity Read ↗

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