Article
Influence of age and HLA type on interferon-gamma (IFN-gamma) responses to a naturally occurring polymorphic epitope of Plasmodium falciparum liver stage antigen-1 (LSA-1).
Clinical and experimental immunology - 1 Oct 2000
Bucci K, Kastens W, Hollingdale M R, Shankar A, Alpers M P, King C L, Kazura J W
Abstract excerpt
Antigenic polymorphism and HLA restriction may limit the immunogenicity of a subunit vaccine against liver-stage Plasmodium falciparum. We examined 59 clinical isolates and five laboratory clones of P. falciparum for polymorphism in the N- and C-terminal regions of LSA-1, evaluated binding of the corresponding peptides to selected HLA class I alleles, and measured IFN-gamma responses in residents of a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.