Article
HLA-DR-promiscuous T cell epitopes from Plasmodium falciparum pre-erythrocytic-stage antigens restricted by multiple HLA class II alleles.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2000
Doolan D L, Southwood S, Chesnut R, Appella E, Gomez E, Richards A, Higashimoto Y I, Maewal A, Sidney J, Gramzinski R A, Mason C, Koech D, Hoffman S L, Sette A
Abstract excerpt
Previously, we identified and established the antigenicity of 17 CD8+ T cell epitopes from five P. falciparum Ags that are restricted by multiple common HLA class I alleles. Here, we report the identification of 11 peptides from the same Ags, cicumsporozoite protein, sporozoite surface protein 2, exported protein-1, and liver-stage Ag-1, that bind between at least five and up to 11 different HLA-DR molecules...
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