Article
Degenerate cytotoxic T cell epitopes from P. falciparum restricted by multiple HLA-A and HLA-B supertype alleles.
Immunity - 1 Jul 1997
Doolan D L, Hoffman S L, Southwood S, Wentworth P A, Sidney J, Chesnut R W, Keogh E, Appella E, Nutman T B, Lal A A, Gordon D M, Oloo A, Sette A
Abstract excerpt
We recently described human leukocyte antigen (HLA) A2, A3 and B7 supertypes, characterized by largely overlapping peptide-binding specificities and represented in a high percentage of different populations. Here, we identified 17 Plasmodium falciparum peptides capable of binding these supertypes...
Topics
- Alleles
- Animals
- CD8-Positive T-Lymphocytes
- Cells, Cultured
- Cytokines
- Epitope Mapping
- Epitopes, T-Lymphocyte
- HLA-A Antigens
- HLA-B Antigens
- Histocompatibility Testing
- Humans
- Phenotype
- Plasmodium falciparum
- Protein Binding