Article
HLA-A2 supertype-restricted cell-mediated immunity by peripheral blood mononuclear cells derived from Malian children with severe or uncomplicated Plasmodium falciparum malaria and healthy controls.
Infection and immunity - 1 Sept 2005
Lyke Kirsten E, Burges Robin B, Cissoko Yacouba, Sangare Lansana, Kone Abdoulaye, Dao Modibo, Diarra Issa, Fernández-Vina Marcelo A, Plowe Christopher V, Doumbo Ogobara K, Sztein Marcelo B
Abstract excerpt
Understanding HLA-restricted adaptive host immunity to defined epitopes of malarial antigens may be required for the development of successful malaria vaccines. Fourteen epitopes of preerythrocytic malarial antigens known to mediate cytotoxic T-lymphocyte responses against target cells expressing HLA-A2-restricted epitopes were synthesized and pooled based on antigen: thrombospondin-related anonymous protein...
Topics
- Adolescent
- Alleles
- Animals
- Antigen Presentation
- Child
- Child, Preschool
- Enzyme-Linked Immunosorbent Assay
- Epitopes
- Erythrocytes
- HLA-A2 Antigen