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Article

Are extensive T cell epitope polymorphisms in the Plasmodium falciparum circumsporozoite antigen, a leading sporozoite vaccine candidate, selected by immune pressure?

Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 2005

Kumkhaek Chutima, Phra-Ek Kooruethai, Rénia Laurent, Singhasivanon Pratap, Looareesuwan Sornchai, Hirunpetcharat Chakrit, White Nicholas J, Brockman Alan, Grüner Anne Charlotte, Lebrun Nicolas, Alloueche Ali, Nosten François, Khusmith Srisin, Snounou Georges

Abstract excerpt

Protective cellular immune responses depend on MHC presentation of pathogen-derived Ag fragments. MHC diversity renders this process sensitive to point mutations coding for altered amino acid sequence of the short target Ag-derived peptides epitopes. Thus, in a given host, a pathogen with an altered epitope sequence will be more likely to escape detection and elimination by the immune system. At a population...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 16148140
DOI: 10.4049/jimmunol.175.6.3935

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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