Molecular analysis of the association of HLA-B53 and resistance to severe malaria.

doi:10.1038/360434a0

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Article

Molecular analysis of the association of HLA-B53 and resistance to severe malaria.

Nature - 3 Dec 1992

Hill A V, Elvin J, Willis A C, Aidoo M, Allsopp C E, Gotch F M, Gao X M, Takiguchi M, Greenwood B M, Townsend A R

Abstract excerpt

The protective association between the human leukocyte antigen HLA-B53 and severe malaria was investigated by sequencing of peptides eluted from this molecule followed by screening of candidate epitopes from pre-erythrocytic-stage antigens of Plasmodium falciparum in biochemical and cellular assays. Among malaria-immune Africans, HLA-B53-restricted cytotoxic T lymphocytes recognized a conserved nonamer peptide...

Topics

Amino Acid Sequence
Animals
Antigens, Protozoan
B-Lymphocytes
Base Sequence
Cell Line
Epitopes
Genetic Variation
HLA Antigens
Histocompatibility Testing
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunity, Innate

Liver

Malaria

Malaria, Falciparum

Molecular Sequence Data

Oligodeoxyribonucleotides

Plasmodium falciparum

Source

Open in PubMed

Identifiers

PMID: 1280333
DOI: 10.1038/360434a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1280333-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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