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Article

A longitudinal study of type-specific antibody responses to Plasmodium falciparum merozoite surface protein-1 in an area of unstable malaria in Sudan.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 1998

Cavanagh D R, Elhassan I M, Roper C, Robinson V J, Giha H, Holder A A, Hviid L, Theander T G, Arnot D E, McBride J S

Abstract excerpt

Merozoite surface protein-1 (MSP-1) of Plasmodium falciparum is a malaria vaccine candidate Ag. Immunity to MSP-1 has been implicated in protection against infection in animal models. However, MSP-1 is a polymorphic protein and its immune recognition by humans following infection is not well understood. We have compared the immunogenicity of conserved and polymorphic regions of MSP-1, the specificity of Ab...

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PMID: 9647243

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