Article
Xenobiotic acceleration of idiopathic systemic autoimmunity in lupus-prone bxsb mice.
Environmental health perspectives - 1 Jan 2001
Pollard K M, Pearson D L, Hultman P, Deane T N, Lindh U, Kono D H
Abstract excerpt
The diverse genetic backgrounds of lupus-prone murine models, which produce both quantitative and qualitative differences in disease expression, may be a valuable resource for studying the influence of environmental exposure on autoimmune disease in sensitive populations. We tested this premise by exposing autoimmune-prone BXSB and the nonautoimmune C57BL/6 mice to the heavy metal mercury. Although both strains...
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