Article
Resistance to xenobiotic-induced autoimmunity maps to chromosome 1.
Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2001
Kono D H, Park M S, Szydlik A, Haraldsson K M, Kuan J D, Pearson D L, Hultman P, Pollard K M
Abstract excerpt
Although evidence indicates that environmental factors play a major role in precipitating systemic autoimmunity in genetically susceptible individuals, little is known about the mechanisms involved. Certain heavy metals, such as mercury, are potent environmental immunostimulants that produce a number of immunopathologic sequelae, including lymphoproliferation, hypergammaglobulinemia, and overt systemic...
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