Article
The effect of toxicokinetics on murine mercury-induced autoimmunity.
Environmental research - 1 May 1998
Hultman P, Nielsen J B
Abstract excerpt
Mercury induces autoantibodies to the nucleolar protein fibrillarin (ANoA) in genetically susceptible (H-2AS) mouse strains. This study examines the importance of mercury toxicokinetics for the induction and strength (titer) of these autoantibodies. Female mice of the inbred strains A.SW and B10....
Topics
- Animals
- Autoantibodies
- Autoimmune Diseases
- Autoimmunity
- Chromosomal Proteins, Non-Histone
- Disease Susceptibility
- Disinfectants
- Dose-Response Relationship, Drug
- Drinking
- Female
- Gene Expression
- Genetic Predisposition to Disease
- H-2 Antigens
- Mercuric Chloride
- Mercury
- Mercury Radioisotopes
- Mice
- Mice, Inbred A
