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Article

Xenobiotic metal-induced autoimmunity: mercury and silver differentially induce antinucleolar autoantibody production in susceptible H-2s, H-2q and H-2f mice.

Clinical and experimental immunology - 1 Mar 2003

Hansson M, Abedi-Valugerdi M

Abstract excerpt

Xenobiotic-metals such as mercury (Hg) and silver (Ag) induce an H-2 linked antinucleolar autoantibody (ANolA) production in susceptible mice. The mechanism for induction of ANolA synthesis is not well understood. However, it has been suggested that both metals interact with nucleolar proteins and reveal cryptic self-peptides to nontolerant autoreactive T cells, which in turn stimulate specific autoreactive B...

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Identifiers

PMID: 12605692
DOI: 10.1046/j.1365-2249.2003.02085.x
PMCID: PMC1808646

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Source receipt: pubmed, retrieved 7 Sept 2026.

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