Article
Identification of cyclic ADP-ribose-dependent mechanisms in pancreatic muscarinic Ca(2+) signaling using CD38 knockout mice.
The Journal of biological chemistry - 5 Jan 2001
Fukushi Y, Kato I, Takasawa S, Sasaki T, Ong B H, Sato M, Ohsaga A, Sato K, Shirato K, Okamoto H, Maruyama Y
Abstract excerpt
We showed that muscarinic acetylcholine (ACh)-stimulation increased the cellular content of cADPR in the pancreatic acinar cells from normal mice but not in those from CD38 knockout mice. By monitoring ACh-evoked increases in the cytosolic Ca(2+) concentration ([Ca(2+)](i)) using fura-2 microfluorimetry, we distinguished and characterized the Ca(2+) release mechanisms responsive to cADPR. The Ca(2+) response from...
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