Article
Mutant Mice With Calcium-Sensing Receptor Activation Have Hyperglycemia That Is Rectified by Calcilytic Therapy.
Endocrinology - 1 Aug 2017
Babinsky Valerie N, Hannan Fadil M, Ramracheya Reshma D, Zhang Quan, Nesbit M Andrew, Hugill Alison, Bentley Liz, Hough Tertius A, Joynson Elizabeth, Stewart Michelle, Aggarwal Abhishek, Prinz-Wohlgenannt Maximilian, Gorvin Caroline M, Kallay Enikö, Wells Sara, Cox Roger D, Richards Duncan, Rorsman Patrik, Thakker Rajesh V
Abstract excerpt
The calcium-sensing receptor (CaSR) is a family C G-protein-coupled receptor that plays a pivotal role in extracellular calcium homeostasis. The CaSR is also highly expressed in pancreatic islet α- and β-cells that secrete glucagon and insulin, respectively. To determine whether the CaSR may influence systemic glucose homeostasis, we characterized a mouse model with a germline gain-of-function CaSR mutation,...
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