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Article

Driver Mutations of Pancreatic Cancer Affect Ca2+ Signaling and ATP Production.

Function (Oxford, England) - 1 Jan 2023

Stopa Kinga B, Łoziński Filip, Kusiak Agnieszka A, Litewka Jacek, Krzysztofik Daria, Mosiołek Sylwester, Morys Jan, Ferdek Paweł E, Jakubowska Monika A

Abstract excerpt

Glandular pancreatic epithelia of the acinar or ductal phenotype may seem terminally differentiated, but they are characterized by remarkable cell plasticity. Stress-induced trans-differentiation of these cells has been implicated in the mechanisms of carcinogenesis. Current consensus links pancreatic ductal adenocarcinoma with onco-transformation of ductal epithelia, but under the presence of driver mutations in...

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PMID: 37575483
DOI: 10.1093/function/zqad035
PMCID: PMC10413928

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