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Article

Ca2+ sparks in embryonic mouse skeletal muscle selectively deficient in dihydropyridine receptor alpha1S or beta1a subunits.

Biophysical journal - 1 Feb 1999

Conklin M W, Powers P, Gregg R G, Coronado R

Abstract excerpt

Ca2+ sparks are miniature Ca2+ release events from the sarcoplasmic reticulum of muscle cells. We examined the kinetics of Ca2+ sparks in excitation-contraction uncoupled myotubes from mouse embryos lacking the beta1 subunit and mdg embryos lacking the alpha1S subunit of the dihydropyridine receptor. Ca2+ sparks occurred spontaneously without a preferential location in the myotube. Ca2+ sparks had a broad...

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Identifiers

PMID: 9929471
DOI: 10.1016/S0006-3495(99)77233-4
PMCID: PMC1300071

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