Article
An NAADP-gated two-pore channel targeted to the plasma membrane uncouples triggering from amplifying Ca2+ signals.
The Journal of biological chemistry - 3 Dec 2010
Brailoiu Eugen, Rahman Taufiq, Churamani Dev, Prole David L, Brailoiu G Cristina, Hooper Robert, Taylor Colin W, Patel Sandip
Abstract excerpt
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a ubiquitous messenger proposed to stimulate Ca(2+) release from acidic organelles via two-pore channels (TPCs). It has been difficult to resolve this trigger event from its amplification via endoplasmic reticulum Ca(2+) stores, fuelling speculation that archetypal intracellular Ca(2+) channels are the primary targets of NAADP. Here, we redirect TPC2 from...
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