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Article

Suppression of Rad leads to arrhythmogenesis via PKA-mediated phosphorylation of ryanodine receptor activity in the heart.

Biochemical and biophysical research communications - 26 Sept 2014

Yamakawa Hiroyuki, Murata Mitsushige, Suzuki Tomoyuki, Yada Hirotaka, Ishida Hideyuki, Aizawa Yoshiyasu, Adachi Takeshi, Kamiya Kaichiro, Fukuda Keiichi

Abstract excerpt

Ras-related small G-protein Rad plays a critical role in generating arrhythmias via regulation of the L-type Ca(2+) channel (LTCC). The aim was to demonstrate the role of Rad in intracellular calcium homeostasis by cardiac-Specific dominant-negative suppression of Rad. Transgenic (TG) mice overexpressing dominant-negative mutant Rad (S105N Rad TG) were generated. To measure intracellular Ca(2+) concentration...

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Identifiers

PMID: 25193703
DOI: 10.1016/j.bbrc.2014.08.126

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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