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Article

Pharmacological and genetic inhibition of calcineurin protects against carbachol-induced pathological zymogen activation and acinar cell injury.

American journal of physiology. Gastrointestinal and liver physiology - 15 Apr 2012

Muili Kamaldeen A, Ahmad Mahwish, Orabi Abrahim I, Mahmood Syeda M, Shah Ahsan U, Molkentin Jeffery D, Husain Sohail Z

Abstract excerpt

Acute pancreatitis is a major health burden for which there are currently no targeted therapies. Premature activation of digestive proenzymes, or zymogens, within the pancreatic acinar cell is an early and critical event in this disease. A high-amplitude, sustained rise in acinar cell Ca(2+) is required for zymogen activation. We previously showed in a cholecystokinin-induced pancreatitis model that a potential...

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Identifiers

PMID: 22323127
DOI: 10.1152/ajpgi.00545.2011
PMCID: PMC3355562

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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