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Article

Overexpression of human CD38/ADP-ribosyl cyclase enhances acetylcholine-induced Ca2+ signalling in rodent NG108-15 neuroblastoma cells.

Neuroscience research - 1 Mar 2007

Higashida Haruhiro, Bowden Sarah E H, Yokoyama Shigeru, Salmina Alla, Hashii Minako, Hoshi Naoto, Zhang Jia-Sheng, Knijnik Rimma, Noda Mami, Zhong Zen-Guo, Jin Duo, Higashida Kazuhiro, Takeda Hisashi, Akita Tenpei, Kuba Kenji, Yamagishi Sayaka, Shimizu Noriaki, Takasawa Shin, Okamoto Hiroshi, Robbins Jon

Abstract excerpt

The role of cyclic ADP-ribose (cADPR) and its synthetic enzyme, CD38, as a downstream signal of muscarinic acetylcholine receptors (mAChRs) was examined in neuroblastoma cells expressing M1 mAChRs (NGM1). NGM1 cells were further transformed with both wild-type and mutant (C119K/C201E) human CD38. The dual transformed cells exhibited higher cADPR formation than ADPR production and elevated intracellular free...

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Identifiers

PMID: 17173996
DOI: 10.1016/j.neures.2006.11.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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