Article

Ryanodine receptor 1 is dispensable for CD4 <sup>+</sup> T-cell differentiation and effector function in intestinal inflammation models

2026-01-15

Abstract excerpt

T-cell receptor signaling is necessary for the activation and differentiation of CD4⁺ T cells. Calcium (Ca 2+ ) signaling is essential for this process, and the complexity of Ca 2+ channels presents a potential therapeutic target for modulating the strength of T-cell receptor signaling and further differentiation of CD4⁺ T cells. Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent Ca 2+ -mobilizin...

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Literature Corpus work: 63ed2b5c-02ad-54be-8513-ae4b08aaa2c7
DOI: 10.64898/2026.01.14.699480

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