Article
Gene expression: long-term gene silencing by RNAi.
Nature - 24 Aug 2006
Vastenhouw Nadine L, Brunschwig Karin, Okihara Kristy L, Müller Fritz, Tijsterman Marcel, Plasterk Ronald H A
Abstract excerpt
Small RNA molecules participate in a variety of activities in the cell: in a process known as RNA interference (RNAi), double-stranded RNA triggers the degradation of messenger RNA that has a matching sequence; the small RNA intermediates of this process can also modify gene expression in the nucleus. Here we show that a single episode of RNAi in the nematode Caenorhabditis elegans can induce transcriptional...
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