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Article

Identification of genes in toxicity pathways of trinucleotide-repeat RNA in C. elegans.

Nature structural & molecular biology - 1 Aug 2014

Garcia Susana M D A, Tabach Yuval, Lourenço Guinevere F, Armakola Maria, Ruvkun Gary

Abstract excerpt

Myotonic dystrophy disorders are caused by expanded CUG repeats in noncoding regions. Here we used Caenorhabditis elegans expressing CUG repeats to identify genes that modulate the toxicity of such repeats. We identified 15 conserved genes that function as suppressors or enhancers of CUG repeat-induced toxicity and that modulate formation of nuclear foci by CUG-repeat RNA. These genes regulate CUG repeat-induced...

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PMID: 25038802
DOI: 10.1038/nsmb.2858
PMCID: PMC4125460

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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