Article
What can knockout mice contribute to an understanding of hypertension?
Current hypertension reports - 1 Apr 2000
Audoly L P, Le T H, Coffman T M
Abstract excerpt
The generation of knockout mice using homologous recombination in embryonic stem cells is a powerful tool for physiologic investigations. This experimental approach has provided unique insights into the study of hypertension. Studies using knockout mice have shed new light on blood pressure regulatory mechanisms, molecular mechanisms of end-organ injury, and genetic mechanisms for hypertension. With the...
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