Article
Arginase II knockout mouse displays a hypertensive phenotype despite a decreased vasoconstrictory profile.
Hypertension (Dallas, Tex. : 1979) - 1 Aug 2009
Huynh Ngan N, Andrews Karen L, Head Geoffrey A, Khong Sacha M L, Mayorov Dmitry N, Murphy Andrew J, Lambert Gavin, Kiriazis Helen, Xu Qi, Du Xiao-Jun, Chin-Dusting Jaye P F
Abstract excerpt
Arginase upregulation is associated with aging and cardiovascular diseases. In this study we report on the cardiovascular phenotype of the arginase II knockout (KO) mouse. We demonstrate that vascular sensitivity and reactivity altered over time in these animals such that no influence on responses to vasoconstrictor activity was observed in 7-week-old KO mice, but dampened responses to norepinephrine and...
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