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Article

New insights into the role of angiotensin-converting enzyme obtained from the analysis of genetically modified mice.

Journal of molecular medicine (Berlin, Germany) - 1 Jun 2008

Shen Xiao Z, Xiao Hong D, Li Ping, Lin Chentao X, Billet Sandrine, Okwan-Duodu Derick, Adams Jon W, Bernstein Ellen A, Xu Yi, Fuchs Sebastien, Bernstein Kenneth E

Abstract excerpt

Angiotensin-converting enzyme (ACE) has been well-recognized for its role in blood pressure regulation. ACE is made by many tissues, though it is most abundantly expressed on the luminal surface of vascular endothelium. ACE knockout mice show a profound phenotype with low blood pressure, but also with hemopoietic and developmental defects, which complicates understanding the biological functions of ACE in...

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Identifiers

PMID: 18443752
DOI: 10.1007/s00109-008-0325-3
PMCID: PMC6167991

Genes

ACE

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