Article
The critical role of tissue angiotensin-converting enzyme as revealed by gene targeting in mice.
The Journal of clinical investigation - 15 May 1997
Esther C R, Marino E M, Howard T E, Machaud A, Corvol P, Capecchi M R, Bernstein K E
Abstract excerpt
Angiotensin-converting enzyme (ACE) generates the vasoconstrictor angiotensin II, which plays a critical role in maintenance of blood pressure in mammals. Although significant ACE activity is found in plasma, the majority of the enzyme is bound to tissues such as the vascular endothelium. We used targeted homologous recombination to create mice expressing a form of ACE that lacks the COOH-terminal half of the...
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