Gene targeting in physiological investigations: studies of the renin-angiotensin system.

doi:10.1152/ajprenal.1998.274.6.F999

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Article

Gene targeting in physiological investigations: studies of the renin-angiotensin system.

The American journal of physiology - 1 Jun 1998

Coffman T M

Abstract excerpt

Gene targeting using homologous recombination in embryonic stem cells provides an avenue for the direct application of precise molecular genetic interventions to the study of complex systems in whole animals. As such, it represents a powerful approach for physiological investigation. Although its...

Topics

Angiotensin I
Angiotensin II
Animals
Blood Pressure
Gene Targeting
Kidney
Mice
Mice, Transgenic
Mutation
Peptidyl-Dipeptidase A
Receptors, Angiotensin
Renin-Angiotensin System

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