Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene targeting in physiological investigations: studies of the renin-angiotensin system.

The American journal of physiology - 1 Jun 1998

Coffman T M

Abstract excerpt

Gene targeting using homologous recombination in embryonic stem cells provides an avenue for the direct application of precise molecular genetic interventions to the study of complex systems in whole animals. As such, it represents a powerful approach for physiological investigation. Although its applications in physiology were initially limited because of technical difficulties in performing whole animal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Pressure
Share to Gene Targeting
Share to Kidney

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Mutation

Share to Peptidyl-Dipeptidase A

Share to Receptors, Angiotensin

Source

Identifiers

PMID: 9841511
DOI: 10.1152/ajprenal.1998.274.6.F999

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene targeting in physiological investigations: studies of the renin-angiotensin system.PMID 9841511Read ↗

The critical role of tissue angiotensin-converting enzyme as revealed by gene targeting in mice.Semantic proximity Read ↗

A genetically clamped renin transgene for the induction of hypertension.Semantic proximity Read ↗

Renin–angiotensin system research: from molecules to the whole bodySemantic proximity Read ↗

A genetic approach for studying the physiology of the type 1A (AT1A) angiotensin receptor.Semantic proximity Read ↗

What can knockout mice contribute to an understanding of hypertension?Semantic proximity Read ↗

Hypertension, kidney, and transgenics: a fresh perspective.Semantic proximity Read ↗

Exploring type I angiotensin (AT<sub>1</sub>) receptor functions through gene targetingSemantic proximity Read ↗

Transgenic mice as a tool to study the renin-angiotensin system.Semantic proximity Read ↗

Animal models of hypertension: an overview.Semantic proximity Read ↗

Gene targeting approaches to complex genetic diseases: atherosclerosis and essential hypertension.Semantic proximity Read ↗

Cardiovascular and renal phenotyping of genetically modified mice: a challenge for traditional physiology.Semantic proximity Read ↗

The Cre/loxP system and gene targeting in the kidneySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.