Article
The action mode of the ribosome-inactivating protein alpha-sarcin.
Journal of biomedical science - 1 Jan 2000
Hwu L, Huang K, Chen D, Lin A
Abstract excerpt
Based on the tertiary structure of the ribosome-inactivating protein alpha-sarcin, domains that are responsible for hydrolyzing ribosomes and naked RNA have been dissected. In this study, we found that the head-to-tail interaction between the first amino beta-strand and the last carboxyl beta-strand is not involved in catalyzing the hydrolysis of ribosomes or ribonucleic acids. Instead, a four-strand pleated...
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