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Article

The R3H domain stabilizes poly(A)-specific ribonuclease by stabilizing the RRM domain.

Biochemical and biophysical research communications - 7 Sept 2007

Liu Wei-Feng, Zhang Ao, He Guang-Jun, Yan Yong-Bin

Abstract excerpt

Poly(A)-specific ribonuclease (PARN), a key enzyme involved in eukaryotic mRNA decay, contains one catalytic domain and two RNA-binding domains. Here we found that at least one RNA-binding domain is required for the substrate binding, but not for the catalysis of PARN. The removal of the R3H domain led to a dramatic decrease in PARN stability and a change in the aggregation kinetic regime, while only minor...

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Identifiers

PMID: 17624302
DOI: 10.1016/j.bbrc.2007.06.139

Genes

PARN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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