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Article

The electrostatic character of the ribosomal surface enables extraordinarily rapid target location by ribotoxins.

Nature structural & molecular biology - 1 May 2006

Korennykh Alexei V, Piccirilli Joseph A, Correll Carl C

Abstract excerpt

Alpha-sarcin ribotoxins comprise a unique family of ribonucleases that cripple the ribosome by catalyzing endoribonucleolytic cleavage of ribosomal RNA at a specific location in the sarcin/ricin loop (SRL). The SRL structure alone is cleaved site-specifically by the ribotoxin, but the ribosomal context enhances the reaction rate by several orders of magnitude. We show that, for the alpha-sarcin-like ribotoxin...

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Identifiers

PMID: 16604082
DOI: 10.1038/nsmb1082
PMCID: PMC1847776

Genes

SRL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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