Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanism of action of RNase T. II. A structural and functional model of the enzyme.

The Journal of biological chemistry - 20 Dec 2002

Zuo Yuhong, Deutscher Murray P

Abstract excerpt

A detailed structural and functional model of E. coli RNase T was generated based on sequence analysis, homology modeling, and experimental observation. In the accompanying article, three short sequence segments (nucleic acid binding sequences (NBS)) important for RNase T substrate binding were identified. In the model, these segments cluster to form a positively charged surface patch. However, this patch is on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dimerization
Share to Amino Acid Motifs
Share to Catalysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Exoribonucleases

Share to RNA, Transfer

Share to Software

Share to Structure-Activity Relationship

Share to Temperature

Source

Identifiers

PMID: 12364333
DOI: 10.1074/jbc.M207707200

Genes

DEDD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanism of action of RNase T. II. A structural and functional model of the enzyme.PMID 12364333Read ↗

Mechanism of action of RNase T. I. Identification of residues required for catalysis, substrate binding, and dimerization.Semantic proximity Read ↗

Characterization of the functional domains of Escherichia coli RNase II.Semantic proximity Read ↗

Structural insights into RNA unwinding and degradation by RNase R.Semantic proximity Read ↗

Determination of key residues for catalysis and RNA cleavage specificity: one mutation turns RNase II into a "SUPER-ENZYME".Semantic proximity Read ↗

Bacteriophage T5 dUTPase: Combination of Common Enzymatic and Novel Functions.Semantic proximity Read ↗

Analysis of the functional modules of the tRNA 3' endonuclease (tRNase Z).Semantic proximity Read ↗

Structural characterization of the RNase E S1 domain and identification of its oligonucleotide-binding and dimerization interfaces.Semantic proximity Read ↗

Functional domains of Brevibacillus thermoruber lon protease for oligomerization and DNA binding: role of N-terminal and sensor and substrate discrimination domains.Semantic proximity Read ↗

Two distinct regions on the surface of an RNA-binding domain are crucial for RNase E function.Semantic proximity Read ↗

New insights into the mechanism of RNA degradation by ribonuclease II: identification of the residue responsible for setting the RNase II end product.Semantic proximity Read ↗

The key role of E418 carboxyl group in the formation of Nt.BspD6I nickase active site: Structural and functional properties of Nt.BspD6I E418A mutant.Semantic proximity Read ↗

Electrostatic interactions guide the active site face of a structure-specific ribonuclease to its RNA substrate.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.