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Article

Conserved asparagine residue 54 of alpha-sarcin plays a role in protein stability and enzyme activity.

Biological chemistry - 1 Dec 2004

Siemer Ansgar, Masip Manuel, Carreras Nelson, García-Ortega Lucía, Oñaderra Mercedes, Bruix Marta, Del Pozo Alvaro Martínez, Gavilanes José G

Abstract excerpt

Asparagine 54 of alpha-sarcin is a conserved residue within the proteins of the ribotoxin family of microbial ribonucleases. It is located in loop 2 of the protein, which lacks repetitive secondary structure elements but exhibits a well-defined conformation. Five mutant variants at this residue have been produced and characterized. The spectroscopic characterization of these proteins indicates that the overall...

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Identifiers

PMID: 15653429
DOI: 10.1515/BC.2004.150

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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