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Article

Distinct roles of the R3H and RRM domains in poly(A)-specific ribonuclease structural integrity and catalysis.

Biochimica et biophysica acta - 1 Jun 2013

He Guang-Jun, Zhang Ao, Liu Wei-Feng, Yan Yong-Bin

Abstract excerpt

Deadenylases specifically catalyze the degradation of eukaryotic mRNA poly(A) tail in the 3'- to 5'-end direction with the release of 5'-AMP as the product. Among the deadenylase family, poly(A)-specific ribonuclease (PARN) is unique in its domain composition, which contains three potential RNA-binding domains: the catalytic nuclease domain, the R3H domain and the RRM domain. In this research, we investigated the...

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Identifiers

PMID: 23388391
DOI: 10.1016/j.bbapap.2013.01.038

Genes

PARN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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