Article
Mitochondria unfold precursor proteins by unraveling them from their N-termini.
Nature structural biology - 1 Dec 1999
Huang S, Ratliff K S, Schwartz M P, Spenner J M, Matouschek A
Abstract excerpt
Protein unfolding is a key step in the life cycle of many proteins, including certain proteins that are degraded by ATP-dependent proteases or translocated across membranes. The detailed mechanisms of these unfolding processes are not understood. Precursor proteins are unfolded and imported into mitochondria by a macromolecular machine that spans two membranes and contains at least nine different proteins. Here...
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