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Article

Functional role of the sarcin-ricin loop of the 23S rRNA in the elongation cycle of protein synthesis.

Journal of molecular biology - 8 Jun 2012

Shi Xinying, Khade Prashant K, Sanbonmatsu Karissa Y, Joseph Simpson

Abstract excerpt

The sarcin-ricin loop (SRL) is one of the longest conserved sequences in the 23S ribosomal RNA. The SRL has been accepted as crucial for the activity of the ribosome because it is targeted by cytotoxins such as α-sarcin and ricin that completely abolish translation. Nevertheless, the precise functional role of the SRL in translation is not known. Recent biochemical and structural studies indicate that the SRL is...

Topics

Binding Sites
Conserved Sequence
Endoribonucleases
Escherichia coli
Fungal Proteins
Guanosine Triphosphate
Mutation
Nucleic Acid Conformation
Peptide Chain Elongation, Translational
Peptide Elongation Factor G

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Peptide Elongation Factor Tu

Protein Binding

Protein Biosynthesis

Protein Structure, Secondary

RNA, Bacterial

RNA, Messenger

RNA, Ribosomal

RNA, Ribosomal, 23S

Source

Open in PubMed Open full text

Identifiers

PMID: 22459262
DOI: 10.1016/j.jmb.2012.03.016
PMCID: PMC3348345

Genes

SRL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Functional role of the sarcin-ricin loop of the 23S rRNA in the elongation cycle of protein synthesis.PMID 22459262Read ↗

Characterization of in vitro and in vivo mutations in non-conserved nucleotides in the ribosomal RNA recognition domain for the ribotoxins ricin and sarcin and the translation elongation factors.Semantic proximity Read ↗

Functional role of the C-terminal tail of the archaeal ribosomal stalk in recruitment of two elongation factors to the sarcin/ricin loop of 23S rRNA.Semantic proximity Read ↗

Alteration in location of a conserved GTPase-associated center of the ribosome induced by mutagenesis influences the structure of peptidyltransferase center and activity of elongation factor G.Semantic proximity Read ↗

The phenotype of mutations of the base-pair C2658.G2663 that closes the tetraloop in the sarcin/ricin domain of Escherichia coli 23 S ribosomal RNA.Semantic proximity Read ↗

The phenotype of mutations of G2655 in the sarcin/ricin domain of 23 S ribosomal RNA.Semantic proximity Read ↗

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A pathway for the transmission of allosteric signals in the ribosome through a network of RNA tertiary interactions.Semantic proximity Read ↗

Ribosomal RNA identity elements for recognition by ricin and by alpha-sarcin: mutation in the putative CG pair that closes a GAGA tetraloop.Semantic proximity Read ↗

Structure and stability of variants of the sarcin-ricin loop of 28S rRNA: NMR studies of the prokaryotic SRL and a functional mutant.Semantic proximity Read ↗

Elongation and folding of nascent ricin chains as peptidyl-tRNA on ribosomes: the effect of amino acid deletions on these processes.Semantic proximity Read ↗

Deep mutational analysis of elongation factor eEF2 residues implicated in human disease to identify functionally important contacts with the ribosome.Semantic proximity Read ↗

Interaction of thiostrepton and elongation factor-G with the ribosomal protein L11-binding domain.Semantic proximity Read ↗

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