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Article

MDR 1 activation is the predominant resistance mechanism selected by vinblastine in MES-SA cells.

British journal of cancer - 1 Oct 2000

Chen G K, Durán G E, Mangili A, Beketic-Oreskovic L, Sikic B I

Abstract excerpt

Single-step selection with vinblastine was performed in populations of the human sarcoma cell line MES-SA, to assess cellular mechanisms of resistance to the drug and mutation rates via fluctuation analysis. At a stringent selection with 20 nM vinblastine, resulting in 5-6 logs of cell killing, the mutation rate was 7 x 10(-7)per cell generation. Analysis of variance supported the hypothesis of spontaneous...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 10970691
DOI: 10.1054/bjoc.2000.1371
PMCID: PMC2374671

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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