Article
Decreased mutation rate for cellular resistance to doxorubicin and suppression of mdr1 gene activation by the cyclosporin PSC 833.
Journal of the National Cancer Institute - 1 Nov 1995
Beketic-Oreskovic L, Durán G E, Chen K G, Dumontet C, Sikic B I
Abstract excerpt
BACKGROUND: Various mechanisms can contribute to cellular resistance to doxorubicin. These include expression of the multidrug transporter P-glycoprotein (product of the mdr1 gene [also known as PGY1], Mrp (multidrug resistance-associated protein), the p110 major vault protein, altered glutathion...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Antibiotics, Antineoplastic
- Antineoplastic Combined Chemotherapy Protocols
- Cyclosporins
- DNA Topoisomerases, Type II
- Doxorubicin
- Drug Resistance, Multiple
- Gene Expression Regulation, Neoplastic
- Humans
- Models, Biological