Mutation rates and mechanisms of resistance to etoposide determined from fluctuation analysis.

doi:10.1093/jnci/86.15.1152

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Article

Mutation rates and mechanisms of resistance to etoposide determined from fluctuation analysis.

Journal of the National Cancer Institute - 3 Aug 1994

Jaffrézou J P, Chen K G, Durán G E, Kühl J S, Sikic B I

Abstract excerpt

BACKGROUND: The major known mechanisms of resistance to etoposide include altered expression of its target enzyme, topoisomerase II (Topo II), and the multidrug-resistant phenotypes encoded by the mdr1 and MRP (multidrug resistance-associated protein) genes. There is little information regarding...

Topics

DNA, Complementary
Drug Resistance
Etoposide
Female
Humans
Models, Statistical
Mutation
Polymerase Chain Reaction
Probability
RNA, Neoplasm
Sarcoma
Tumor Cells, Cultured
Uterine Neoplasms

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