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Article

Mutation rates and mechanisms of resistance to etoposide determined from fluctuation analysis.

Journal of the National Cancer Institute - 3 Aug 1994

Jaffrézou J P, Chen K G, Durán G E, Kühl J S, Sikic B I

Abstract excerpt

BACKGROUND: The major known mechanisms of resistance to etoposide include altered expression of its target enzyme, topoisomerase II (Topo II), and the multidrug-resistant phenotypes encoded by the mdr1 and MRP (multidrug resistance-associated protein) genes. There is little information regarding the distribution, frequency, and origin of these mechanisms in cancer cells. PURPOSE: We performed fluctuation analysis...

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Identifiers

PMID: 8028036
DOI: 10.1093/jnci/86.15.1152

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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