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Article

Resistance mechanisms in human sarcoma mutants derived by single-step exposure to paclitaxel (Taxol).

Cancer research - 1 Mar 1996

Dumontet C, Duran G E, Steger K A, Beketic-Oreskovic L, Sikic B I

Abstract excerpt

A fluctuation analysis experiment was performed by exposing 15 expanded populations of MES-SA sarcoma cells to paclitaxel (Taxol) at a concentration of 10 nM for 7 days. The mutation rate was approximately 8 multiplied by 10(-7)/cell generation. ANOVA supports a stochastic cell survival mechanism of spontaneous mutation rather than induction of an adaptive response under these selection conditions. Surviving...

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PMID: 8640766

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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